Modifiers of TAU pathology

Image Ilie Cosmin Stancu
In the context of the CEMO seminars, Ilie Cosmin Stancu will present on Tuesday April, 23 at 12:00 in the Harvey 1 meeting room, the seminar "Modifiers of TAU pathology".
Brains of Alzheimer’s Disease (AD) patients are neuropathological characterized by the presence of amyloid plaques and neurofibrillary tangles, respectively composed of aggregated amyloid peptides and hyperphosphorylated Tau. Several data have indicated beta-amyloid (Abeta) induced aggravation of tau-pathology in in vitro and in vivo models. However, the molecular mechanisms of the communication between Abeta and Tau remain a major black box in the pathogenesis of AD. We here generated a novel model with robust combined amyloid and tau-pathology, providing a preclinical model to evaluate therapeutic targets for their combined and specific modulatory effects on amyloid and tau-pathology. Immunohistochemical data demonstrated a dramatic aggravation of Tau-pathology in mice with combined pathologies. Aggravated Tau-pathology was associated with increased GSK3b-Y216P staining. Longitudinal and spatial immunohistochemical analysis demonstrated that these abnormalities preceded Tau-pathology. Taken together our data further support amyloid-induced Tau-pathology and support a role for dysregulated GSK3b-signaling as contributing molecular mechanisms.
| 23/04/2013 |